Agenda

Date

July 18-19, 2019

Location

Zurich, Switzerland

Conference Agenda

Explore your options to connect, learn and be inspired from our speakers

Keynote Session:

Meetings International -  Conference Keynote Speaker Kholoud Alsowayigh photo

Kholoud Alsowayigh

Jeddah Forensic Medicine Center, Saudi Arabia

Title: Evaluation of alcohol concentrations in samples taken from medico legal cases referred to Jeddah forensic center KSA

Biography:

Kholoud Alsowayigh works as a Forensic consultant at Jeddah Forensic Medicine center. Kholoud alsowayigh has graduated from medical school at king abdulaziz university and is a forensic medicine consultant, Head of training department at forensic medicine center in Jeddah, member of exam committee in SCFHS, supervisor of Saudi board training program in forensic medicine and also serves as Associate editor in Egyptian forensic sciences journal.

Abstract:

The present study investigated the level of alcohol in cases referred to the centre as a post mortem cases and to the assault clinic from 2014 -2018 detection of alcohol is of extreme importance to the investigation and the cause of death. To evaluate the problem on alcohol intake and its relation to nationality, age, and gender and cause of death. Samples used for testing alcohol level: vitros fluid, blood, urine. Alcohol intake in Saudi Arabia is banned, this includes consuming, importing, brewing and selling so all cases suspected for drinking alcohol are referred to the toxicology centre and the forensic centre.

Meetings International -  Conference Keynote Speaker Pirkko-Liisa Tarvonen photo

Pirkko-Liisa Tarvonen

University of Helsinki, Finland

Title: Dental restorations according to Rayo 3Dtoothfill

Biography:

Pirkko-Liisa Tarvonen has a specialist degree in dental public health from the University of Turku, Finland, and a PhD degree from the University of Eastern Finland. She acts as dental marketing director at Rayo 3D-Toothfill Ltd and as University Lecturer at the University of Helsinki and at the University of Eastern Finland. As a voluntary project coordinator for ten years she has had a remarkable contribution in the support of primary dental care and dental education in the Democratic People’s Republic Korea.

Abstract:

Direct filling technique with composite has several shortcomings. Especially larger fillings in posterior teeth are challenging. As result, most restorations need repetitive repair or replacement within a couple of years. Indirect restorations are used to overcome the challenges linked with direct restorations. Subtractive CAD/CAM (computer-aided design and computer-aided manufacturing) milling technology has been generalized along with the expanding role of digitalization. Additive CAD/CAM technique called 3D printing Additive manufacturing may be used to pass challenges linked with milling: material waste, milling accuracy that is dependent on the machining tools, and undercuts or locations that are inaccessible to end-mills cannot be milled. Accuracy of the technology makes it suitable for manufacturing of several dental applications, like surgical guides, aligners and dental implants. RAYO 3DToothFill is a novel technique utilizing digital imaging and 3D printing to fabricate tooth fillings and other dental restorations. Based on our in vitro study, the accuracy of 3D printing technique overcomes that of milling technique in the fabrication of dental inlay and onlay fillings. Additional clinical investigations are planned to carry out during 2019 to confirm the findings. The 3D printing process is fast and likely to be used chairside at the dental office in the future. The technique has been developed by a team of professors and experts from the University of Eastern Finland and University of Oulu.

Meetings International -  Conference Keynote Speaker Vega Julio Cesar photo

Vega Julio Cesar

Laboratorio Pablo Cassara SRL, Argentina

Title: Preservation in medicines, a QbD approach to optimize microbiological quality of pharmaceutical formulations

Biography:

Vega Julio Cesar has graduated in chemistry at the University of Buenos Aires. He holds a degree as master of industrial business administration from Escuela de Organizacion Industrial de Madrid and a postgraduate degree in Industrial Business Administration from Universidad Católica Argentina. He is R&D Manager at Laboratorio Pablo Cassara S.R.L., a pharmaceutical company in Argentina. He is author and co-author of patents related with pharmaceutical formulations and pharmaceutical primary packaging materials. He is co-author of an article on melanoma cells cryopreservation.

Abstract:

Preservatives have long been used in the formulation of liquid and semisolid medicines to ensure microbial quality during their shelf life and use. However, preservatives may cause undesirable effects both topically and systemically and even contribute to antibiotic resistance of microorganisms. Therefore, they should be either avoided or minimized. Within the present regulatory framework of Quality by Design recommended by ICH guidelines, a decision-tree approach is proposed to either avoid or minimize the use of preservatives. An optimization procedure to find the optimal concentration of preservative is described, on the basis of the works of Orth DS. It consists of criteria for the selection and estimated concentration ranges of preservatives for a certain formulation coupled with a procedure to estimate D values for different microorganisms. D value is a quantitative measure of preservative efficacy of the formulation, allowing the use of regression analysis to optimize preservative concentration and other formulation parameters, thus accelerating and improving the process of formulation development.

Oral Session 1:

  • Applied Pharmacology | Pharmacogenetics and Pharmacogenomics | Drug Screening and Discovery
Meetings International - Dentistry 2019 Conference Keynote Speaker Ryong Nam Kim photo

Ryong Nam Kim

Seoul National University, Korea

Title: Pathogenic mosaic germline mutational landscape in breast cancer patients and pharmacogenomics

Biography:

Ryong Nam Kim had completed his PhD in a major of functional genomics and has his expertise in discovering biomarker and pharmaceutic drug candidates by applying genomics and pharmacogenomics approaches to diverse cancer types, including breast, lung and stomach cancers.

Abstract:

In recent years, a huge number of germline mutational variants had been identified in breast cancer by next-generation sequencing technologies. Even though a considerable portion of them are variants with low variant allele fraction (< 30%), which could give rise to suspicion among us regarding whether they might be false or true, recent pioneering studies have begun to corroborate that a certain amount of them are true variants associated with mutational mosaicism. In this study, we present pathogenic mosaic germline mutational landscape in 490 breast cancer patients by carrying out targeted next-generational sequencing of 62 cancer-associated genes. We discovered 112 pathogenic, 37 likely pathogenic and 252 VUS mosaic germline mutations with variant allele fraction less than 30%. PRSS1 (97%), ATM (22%), PMS2 (11%), BARD1 (11%), PTEN (8%), BRCA2 (8%), BRCA1 (7%), APC (5%), MSH2 (5%) and NF1 (5%) mosaic mutations occurred in the top 10 biggest portions among the 490 patients, respectively. Gene pairs showing statistically significant mutual exclusivity in mutation carriers are PRSS1 and FANCC (p < 0.01), PRSS1 and PTEN (P < 0.01), and PRSS1 and ATM (p < 0.01). Genes showing the biggest fractions of mosaic mutational clusters PRSS1 (FDR < 10-6), BARD1 (FDR < 10-5), PTEN (FDR < 10-4), ATM (FDR < 10-4), VHL (FDR < 10-4), PMS2 (FDR < 10-4), NBN (FDR < 10-3), PTCH (FDR < 10-3), MSH6 (FDR < 10-3), and BRCA2 (FDR < 10-2). Protein pfam domain hit most by those mosaic mutations is Tryp_SPc (trypsin-like serine protease). The most affected pathways by mosaic mutations are TP53, cell cycle, RTK-RAS and PI3K pathways. By using 34 drug-gene mutation interaction database sources for clinically actionable pathogenic mutations, we identified drug candidates for most of mosaic pathogenic mutations in this study. Furthermore, by using pharmacogenomics approach through integrating drug sensitivity, genomic mutation and expression profiling data for 1200 human cancer cell lines, we validated the drug sensitivity and effectiveness of NVP-BEZ235 and temsirolimus for RB1, Camptothecin for TP53, and AZD8055 for NF1 and MSH2 mutated cancer cell lines. Taken together, this study elucidates pathogenic mosaic germline mutational landscape in breast cancer patients and also provides pharmacologists, clinicians, clinical oncologists and surgeons with fresh guidance for choosing candidate pharmaceutical drugs for carriers with pathogenic mosaic germline mutations and for diagnosing and treating them.

Meetings International - Dentistry 2019 Conference Keynote Speaker Saeed Taheri photo

Saeed Taheri

Shahid Beheshti University of Medical Sciences, Iran

Title: An introduction to pharmacoeconomics, health technology assessment, and multiple-criteria decision analysis

Biography:

Saeed Taheri has graduated as doctor of pharmacy in 2016 from Shahid Beheshti University of Medical science, Tehran, Iran and started PhD courses in "Pharmacoeconomics and Pharma Management”. He is a member in Health economics committee in Tehran chamber of commerce since 2017 and working as pharmacoeconomic advisor in some pharmaceutical companies. He has contributed in 34 cost-effectiveness projects, published more than 13 papers in reputed journals, supervised and still supervising 8 master theses, and has been serving as an editorial board member of some journals. He was selected as recipient of an ISPOR research presentation award at ISPOR Europe 2018, 10-14 November, Barcelona, Spain for the best presentation. He also awarded from "The first Euro-Asian congress of pharmacoepidemiology 2018" for the best presentation.

Abstract:

Given increasing constraints on health care resources and cost, there is a need to assess the relative value of high efficacy therapies for different disease including cancers. In addition, decision makers in middle-income countries also need to manage certain therapeutic categories, especially for chronic disease such as MS, in an attempt to control costs and give access to new, often more expensive, therapies within limited health care budgets. For countries with limited resources, economic evaluations based on decision analytic modeling may be a suitable alternative to extensive trial-based economic evaluations. In this presentation, we are going to review the principals of the methods which are common to investigate the value of new therapies including cost-effectiveness studies, Health Technology Assessment (HTA), and Multiple-criteria decision analysis (MCDA). First of all, the concept of cost in pharmacoeconomics would be reviewed in terms of different perspectives such as payer, health system, and etc. Then, different consequences will be reviewed focusing on the concept of utility and Quality Adjusted Life Years (QALYs). Subsequently, cost-effectiveness plane would be reviewed interpreting the willingness-to-pay threshold for choosing the cost-effective strategies. Then, two common modeling approaches (decision tree and Markov models) would be reviewed. Afterwards, the limitation of cost-effectiveness studies will be discussed together with the concept of deterministic and probabilistic sensitivity analysis. Finally, the HTA and MCDA methods would be reviewed as alternative or complementary methods to cost-effectiveness studies. In view of a tight healthcare budget, these decision analysis methods may provide healthcare decision makers with the requisite insights to make informed choices.

Meetings International - Dentistry 2019 Conference Keynote Speaker Ramin Ataee photo

Ramin Ataee

Mazandaran University of Medical Sciences, Iran

Title: Evaluation of curcumin nano-micelle on of 1,2, dimethylhydrazine-induced rat colon carcinogenesis in comparison with 5FU

Biography:

Ramin Ataee has received PhD in pharmacoloy from Tehran Uninversity of Medical Sciences in 2009. He has worked at Researcher of Institute Pasteur, Amol Branch 2000-2012.  He is an assistant professor of pharmacology MUMS 2012. He has received 6 months scholarship QIMR, Brisbane Australia 2009. He is in editorial board of sciafrijournal, Editorial board of International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) He has p ublished 46 articles and 2 books. He is a member of Iranian pharmacy council, Iranian Medical council and Australian Society of Medical research (ASMR). His fields of research focuses on cancer pharmacology, neuro-pharmacology, herbal medicine researches and diabetes.

Abstract:

Objective: Curcumin is a natural polyphenolic substance with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility, rapid metabolism and low bioavailability, hence the need for suitable carriers. In the present study we aimed to evaluate effects of polymeric micelles of curcumin on experimental colon cancer model in Rat.

Method: Pathogen-free male Sprague–Dawley rats divided into 4 groups. animals from group A, B, C started to receive DMH intraperitoneal injection once a week at a dose of 20 mg/kg body weight in 0.9% normal saline. Group A served as DMH control. B, C were treated with nano-micelle curcumin and 5-FU respectively starting 4 weeks before first carcinogen challenge and continued till week 30 of experimentation. At the end of the 4 weeks all animals were killed by cervical dislocation.and their colon removed and investigated for morphological and immunohistochemistry studies of apoptosis which expression of Bcl2, BAX and Caspase9 have been investigated.

Results: Morphological changes in Nano-curcumin groups was significant compared with DMH group but in protein expression of apoptotic factors, although decrease in Bcl2 expression and increase in BAX and caspase9 occurred in Nano-micelle group but these changes were not significant compared with DMH group(P>0.05)

Conclusion: According to results of this study, Nano-micelle of curcumin has some preventive effect in experimental model of colon cancer in vivo but has not induced apoptotic effect completely and more complementary studies are needed.

Oral Session 2:

  • Dentistry and Dental Anatomy | Prosthodontics and Endodontics
Meetings International - Dentistry 2019 Conference Keynote Speaker Ahmad Mohammad Saeed Hammad photo

Ahmad Mohammad Saeed Hammad

Aburrub Dental Clinic, Jordan

Title: Endodontic irrigation solutions

Biography:

Ahmad Mohammad Said Hammad is working as a dentist at Aburrub Dental Clinic, Jordan. He has completed his bachelor’s degree in oral and dental medicine and surgery in the year of 2015. He has attended many scientific conferences and gets certified.

Abstract:

The goal of endodontic treatment is to remove all the vital and necrotic tissues, microorganisms and microbial byproducts from root canal system. This goal can be achieved through chemical and mechanical debridement of root canals. This article narrates the specifics and requirements of the irrigation solutions. Sodium hypochlorite is proposed as the primary irrigant by virtue of its organic tissue dissolution capacity and broad antimicrobial properties. On the other hand, chelation solutions are recommended as auxiliary solutions to remove the smear layer or to hinder its formation on dentin surface. Thus, it's hoped that sealers and root canal fillers can penetrate to dentin tubules and obturate the canals hermetically. There are new studies on traditional irrigants especially on some irrigants that can replace sodium hypoclorite. This article reviews the new irrigants which can be used in future endodontic practice, and their advantages and limitations. Moreover, actions and interactions of recently used irrigants are adverted.

Meetings International - Dentistry 2019 Conference Keynote Speaker Vasilios Piperias photo

Vasilios Piperias

Private clinic in Dubai, UAE

Title: Impacted teeth: Diagnosis and therapeutic approach

Biography:

Vasilios Piperias DDS, graduated from the Kapodistrian University of Athens, Dental Faculty in 1999. He got his first MSc in Oral Biology from the same University on 2004 and the second one, MSc in Oral Pathobiology- Oral Surgery on 2008. In 2003 he attended the Clinic for Oral Surgery and Stomatology in the University of Bern (Switzerland). He has participated as a clinical assistant in the Clinic of Oral and MaxilloFacial Surgery in University of Athens for pre-graduated students. He is a member in several international and national associations such us ITI (International Team of Implantology), Hellenic Society of Osseointegration, Hellenic Society of Periodontology, European Federation of Periodontology, Dental Association of Athens and others.

Abstract:

The presentation will give an overview in the impacted teeth problems and how can we solve them. An impacted tooth is a tooth that is not erupted fully or at all in the oral cavity. Its related to the space provided for the teeth in the mandible and maxilla and to the time of eruption of each tooth. Therefore the most common impacted teeth are the third molars, then the canines and much less premolars and lateral incisors. The impacted teeth may have or not symptoms such as pain, swollen, infection in the adjacent gums, crowded teeth, open space (mainly in canines and lateral insicors), difficulty in mouth opening and sometimes even headaches. This lecture will provide the tools we have in our hands for the diagnosis of the type of impaction, (OPG, CBCT) and therefore the treatment plan which must be chosen for the better result. We will discuss the surgical techniques best fits in each type of tooth impaction for the best treatment outcome, as well as the preoperative and post-operative approach in order to help the patient receive the best treatment. We will see the possible obstacles we might face in the treatment of such cases. We will discuss also the collaboration with the Orthodontist in cases where the teeth needs to be erupted in the oral cavity. We will discuss also the possible complications during or after the surgical procedure and how we can manage them.

Meetings International - Dentistry 2019 Conference Keynote Speaker Sonia Jaafoura photo

Sonia Jaafoura

Private practice for Hypnotherapy in UAE, France

Title: Hypnotherapy: A new and efficient way to ease the uncooperative dental patient

Biography:

Sonia Jaafoura has completed her BDS in 1995 in English Studies, Faculty of Letters, at the age of 25 years from Sousse University Tunisia, and A training course in Manchester University, England. She attended her Hypnotherapist Certificate with EKKA in Dubai, and she is the Director of “Skopos”, Hypnotherapy Treatment Center.

Abstract:

The present lecture will reveal a new approach to improve the behaviour and response of the frightened and uncooperative patient who visits a dental clinic for the everyday general dental treatment as well as excessive or more advanced treatment plans. Dental anxiety, fear, and phobia are all related terms that need to be clearly clarified. According to numerous Dental Fear Surveys (DFS), between 10% and 20% of adults in the United States avoid seeking regular dental treatment due to extreme dental fear. Through the use of the Hypnotherapy treatment we are able to flip the patients’ discomfort fear and phobia towards the dentist and the dental procedures in to acceptance and tolerance. The psychological trauma the dental treatment has created in the past or in the present situation can effectively be cured by this approach. Through this lecture we will discover the ways (Theory of the mind, flip, etc), the trends (cognitive therapy, self- awareness etc) and the opportunities the Hypnotherapy can create, as well as the paths that the Therapist is using in order to flip the whole unpleasant and uncomfortable experience of a dental treatment to a positive one. It is a great new “tool” in the dentist’s quiver to approach more effectively and with better long term results his/her patients’ fears and discomforts. And as every dentist knows a happy patient makes to more satisfied and happy dentist.